The news is not good for the Titans, who already trail early in Houston.
Quarterback Jake Locker left the game after taking a massive hit for a sack by unblocked safety Glover Quin. He walked off the field and was taken to the locker room.
Early indications are he has an injury to his left, non-throwing shoulder.
Matt Hasselbeck took over at quarterback for Tennessee, he took over for Locker in Week one vs the Pats when Locker injured his left shoulder making a tackle after a turnover.